Amino acids and Anti-Aging

Amino acids as a component of antiaging medicine

 




Probably the most popular medical topic over the last years has been an issue of possible strategy of stopping or at least slowing the processes of human body ageing and disintegration.

And it is not a surprise that all of us want to become adult, but none of us want to be old or to feel like that.

It is hard to say whether this wish will be fulfilled or not in the near future.

Nevertheless, the knowledge acquired by scientists on the reasons of ageing processes and fight against it are so promising that they become a source of absolutely new branch of preventive medicine – antiaging medicine.

Amino acids can be considered a component of antiaging medicine.

Hormonal changes

If to speak about hormonal changes the most important is a decrease in the level of sex hormones, first of all, estrogens (menopause), testosterone (andropause) and dehydroepiandrosterone (DHEA) or DHEA sulfate (andrenopause).

Besides, there is also a decrease in growth hormone level (somatopause). In recent times special emphasis has been laid on decrease in growth hormone levels as a mean of progression of ageing processes.

Growth hormone (somatotropic hormone, somatotropine, somatotrophic hormone) is synthetized by pituitary body. Its release is regulated by Somatotropin Releasing Factor, STG-RF and somatostatin, synthetized by hypothalamus. This impact is produced partially not by growth hormone, but by Insulin-like growth factor 1, which is released in the liver under the influence of the growth hormone. The most important physiological functions of the growth hormone are participation in cell division process, tissue growth and in increased consumption of amino acids by muscular tissue cells, stimulation of protein synthesis and lipolysis.

Glutamine

Various amino acids are important for the antiaging medicine first of all because they stimulate release of the growth hormone. The amino acid which in practical conditions has maximum effect is glutamine.
So the persons at the age from 32 up to 64 years who have been taking 2 grams of glutamine, in comparison with placebo group, have shown quadruple increase in concentration of growth hormone in the blood plasma. Author of the study has told that dosages less than 1 g presumably will be insufficient, however much higher amounts can also be not effective because they accelerate glutamine cleavage process in the liver


.
Arginine and lysine

Arginine is also one of amino acids which increase growth hormone release. There was double blind placebo-controlled study in postmenopausal women, so oral daily administration of 9 grams of arginine for 1 month has resulted in ncrease in growth hormone level. One of the studies carried out in Italy, tells that lysine potentiates arginine action. During the period of the study an efficiency of the combined administration of lysine 1200 mg and arginine 1200 mg for male participants of the study at the age from 15 to 20 years old was 10 times higher in comparison with administration of only arginine. One of the studies which participants were healthy elder persons has shown that daily administration of 17 grams of arginine during the period of 14 days provides essential increase in IGF-1. Growth hormone level was not measured in this study.

Glycine

Glycine plays a significant role in synthesis of connective tissue protein. There is high demand for this amino acid at the anabolic phase. Accordingly its insufficient supply results in higher cleavage of connective tissue protein. Glycine does facilitates recalling of the information from the memory (brain functioning). It does also increase ttention in older persons. Thus its efficiency was marked after only one administration in a small dosage (100 mg only) on an empty stomach. Besides, glycine participates in detox reactions in the liver. In case of administration in a pure form it can stimulate higher release of STH (somatotropic hormone, Somatotropine) by the pituitary body. It happens both at intravenous administration in high dosage – from 250 mg per kg of body weight and at oral administration of about 6 grams of  glycine.

 

 

Nutritive substances

per 100 g

Daily portion 6 g

Energy

1556.74 kJ
(372.59 kcal)

93.40 kJ
(22.35 kcal)

Fat

0.0 g

0.0 g

Carbohydrates 11.48 g 0.68 g

Protein

83.33 g

4.99 g

Salt

0 g

0 g

L-glutamine

50,0 g

3,0 g

L-lysine

13,0 g

0,78 g

glycine

12,0 g

0,72 g

L-arginine

11,0 g

0,66 g

 


 



 

Quellen: Felicitas Reglin: Aminosäuren in der Orthomolekularen Medizin 2 Auflage / Ralf Reglin Verlag Köln / Deutschland
11. Aminosäuren als Bestandteil der Anti-Aging-Medizin
Blum A, Cannon RO 3rd, Costello R, Schenke WH, Csako G: Endocrine and Iipid effects of oral L-arginine treatment in healthy postmenopausal women. The journal of Iabaratory and clinical medicine 135, 3 (2000) 231 -237

Dawson R Jr., Liu S, Eppler B, Patterson T: Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats. Mechanisms of Ageing and Development 107 (1999) 73 - 91

Fantenot JM et al.: Die Bedeutung von Melatoninmangel für die Krebsentstehung und pathologische Alterungsprozesse. Journal für Orthomolekulare Medizin 3, 2 (1995) 87 - 92

Hagen TM, Wehr CM, Ames BN: Mitochondrial Decay in Aging. Annals of the New York Academy of Seiences 959 (2002) 214-223

Hipkiss AR: Molecules in focus: Carnosine, a protective, anti-ageing pcptide?, The International Journal of Biochemistry & Cell Biology 30 (1998) 863 - 868

Hurson M, Regan MC, Kirk SJ, Wasserkrug HL, Barbul A: Metabolie cffects of arginine in a healthy elederly population. Journal of parenteral and enteral nutrition 19, 3 (1995) 22 7 - 230

lsidori A, lo Monaco A, Cappa M: A study of growth hormone release in man after oral administration of amino acids. Current medical researeh and opinion 7, 7 (1981) 4 75 - 481

Julius M, lang CA, Gleiberman L, Harburg E, Di France isen W, Schork A: Glutathione and morbidity in a community-based sample of elderl y. J Cl in Epidemol 47, 9 (1994) 1021 - 1026

Krstevska M, Dzhekova-Stojkova S, Bosilkova G: Menopause, coronary artery di sease and antioxidants. Clinical chemistry and Iabaratory medicine 39, 7 (2001) 641 - 644

Lang CA, Naryshkin S, Schneider DL, Mills BL Lindeman RD: Low blood glutathionc Ievels in healthy aging adults. J Lab Clin Med 120 (1992) 720 - 725

Liu J, Atamna H, Kuralsune H, Ames BN: Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Annals of the NewYork Academy of Seiences 959 (2002) 133 - 66

Liu CS, Wei YH: Age-associated alteration of blood thiol-group-related antioxidants in smokers. Environ Res 80, 1 (1999) 18 - 20 Samiec PS, Drews Botsch C, Flagg EW, Kurtz JC, Sternberg P Jr., Reed RL, Jones DP: Glutathione in human plasma: dec line in association with aging, age-rclatcd macul ar degeneration, and diabetes. Free Radic Biol Med 24, 5 (1998) 699 - 704

Seidman MD, Khan MJ, Bai U, Shirwany N, Quirk WS: Biologie activity of mitochondrial metabolites on aging and age-realted hearing loss. The American journal of otology 21, 2 (2000) 161 - 7

Tokunaga K, Kanno K, Ochi M, Nishimiya T, 5hi shino K, Murase M, Makino H, Tokui 5: Lipid peroxide and antioxidants in the elderly. Rinsho Byori 46, 8 (1998) 783 - 789

Welbourne TC: lncreased pl asma bicarbonate and growth hormone after an oral glutamine Ioad. Am J Cl in Nutr 61 (1995) 1058 - 1061

Quellen: Klaus Arndt und Torsten Albers: Protein und Aminosäuren / Novagenics Verlag Arnsberg / Deutschland
I. File SE, Fluck E, Fernandez C. Beneficial effects of glycine (Bioglycin) on memory and attention in young and middle-aged adults. J Cl in Psychopharmacol (1999) 19: 506 - 512.

2. Heresco-Levy U, Javitt DC, Ermilov Met al. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatmentresistant schizophrenia. Br j Psychiatry ( 1996) 169: 610 - 617.

3. javitt DC, Zylberman I, Zukin SR et al. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry (1994) 151: 1234 - 1236.

4. Popa M, Florea I. Growth hormone release by glycine injected intravenously in 22 healthy sexually immature children. Biomedicine (I 975) 23( 4): 131 - 133.

5. Kasai K, Kobayashi M, Shimoda SI. Stimulatory effect of glycine on human growth hormone secretion. Metabolism (1978) 27(2): 201 -  208.

 

 

 
www.xr47plus.com

CMSimple_XH